I have a multi-user configuration setup on my Windows 10 PC at home. My entire family can log into their own Windows account and have their own desktop and storage space. This works nicely but I noticed that iTunes is not very friendly with this multi-user configuration – iTunes hangs after sync’ing with an iPhone/ipad and can’t be used again until after a system reboot. Here’s how I resolved this issue: I created a batch file which terminates iTunes and creates a “clean” state …

1. On the Desktop create a new file called ResetITunes.bat. You can use Windows Notepad or any text editor to do this.
2. Add the following to the ResetITunes.bat file

@echo off

taskkill /F /IM itunes.exe
taskkill /F /IM distnoted.exe

3. Now, whenever you close iTunes, simply run ResetITunes.bat as Administrator (right-click and select “Run as Administrator”) and iTunes will terminate and be ready for the next user to sync their iPhone or iPad.

Hope this helps!